Effect of Hydroxyapatite Toothpaste and Mouthwash in Preventing White Spot Lesions During Orthodontic Treatment
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Prevention of White Spot Lesions in Patients Undergoing Orthodontic Treatment
In brief
This study aims to evaluate the effect of hydroxyapatite-containing toothpaste and mouthwash in preventing white spot lesions in patients undergoing orthodontic treatment. Participants: 75 patients will be divided into three groups: * Group A: Participants will brush their teeth three times a day using hydroxyapatite toothpaste and rinse twice a day with a placebo mouthwash. * Group B: Participants will brush their teeth three times a day using fluoride toothpaste and rinse twice a day with hydroxyapatite mouthwash. * Group C (Control Group): Participants will brush their teeth three times a day using fluoride toothpaste and rinse twice a day with a placebo mouthwash. Patients will be followed during their orthodontic treatment to assess the development of white spot lesions. The study is safe and involves no surgical procedures or risky medications, and will be conducted under the supervision of Principal Investigator Heba Masri after obtaining ethical approval.
Key facts
- Study ID
- NCT07325643
- Run by
- Heba Tahseen Almasri
- People needed
- 75
- Starts
- 2025-11-20
- Expected to finish
- 2026-12-20
- Last updated by the study team
- 2026-01-08
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- 1. History of previous orthodontic treatment. 2. Bleaching or topical fluoridation within the last six months. 3. Severely rotated any of the study teeth (limiting the appearance of facial surfaces).
- Visible signs of caries, fluorosis, hypocalcification, or other developmental defects. 5. Restoration on the labial surface of the study teeth. 6. Systemic or endocrine conditions (e.g., cardiac pacemakers, diabetes mellitus).
- Craniofacial anomalies and clefts.
Where it is running
- University of Baghdad - College of Dentistry / Orthodontic Clinic — Baghdad, Iraq (enrolling)
Full record on ClinicalTrials.gov
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