Quantifying Motor Network Dynamics to Predict and Enhance Outcomes in Pediatric Dystonia

Recruiting now · Not applicable

Conditions studied: Dystonia, Pediatric, Deep Brain Stimulation, Motor Development

In brief

The goal of this study is to understand the development and progression of childhood dystonia, a movement disorder, in children. The main questions it aims to answer are: How does the activity of the neural network evolve in children with dystonia in the context of motor development? What are the effects of chronic and active stimulation on cortical and subcortical motor network function in children with deep brain stimulation (DBS)? Participants will: * Undergo noninvasive electrophysiological measurements (EEG, EMG) to quantify neural network activity. They will be tested at rest and during a simple motor reaction task. * Children with DBS will be assessed in the on and off DBS state to assess effects of chronic and active changes in motor network function.

Key facts

Study ID: NCT07325175
Run by: Children's Hospital Medical Center, Cincinnati
People needed: 75
Starts: 2024-01-01
Expected to finish: 2029-12-31
Last updated by the study team: 2026-06-16

Who can join

Age: 6 and older, up to 21. Sex: any. Healthy volunteers: accepted.

You may qualify if…

For dystonia subjects:
Dx of dystonia (with and without DBS)
willingness and ability to complete study protocols.
For Typically Developing Controls:
normal developmental milestones
absence of any neuropsychiatric disorder
no significant medical condition.

You may not qualify if…

history of epilepsy
presence of implanted medical devices (except DBS in dystonia subjects)
lack of cognitive or physical ability to complete study protocol.

Where it is running

Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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