Evaluation of Irisin Levels in Adult Forearm Fracture Surgery Under Infraclavicular Block and General Anesthesia

Starting soon · Not applicable

Conditions studied: Inflamation, Healing, Angiogenesis

In brief

This randomized prospective study evaluates the effect of general anesthesia versus infraclavicular nerve block on perioperative serum irisin levels in adults undergoing forearm fracture surgery. Irisin levels will be measured preoperatively, at 30 minutes postoperatively, and at 24 hours postoperatively. The association between irisin changes and fracture healing will be explored as a secondary outcome.

Key facts

Study ID

NCT07324681

Run by

Ankara City Hospital Bilkent

People needed

90

Starts

2026-01-25

Expected to finish

2026-05-05

Last updated by the study team

2026-01-09

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18 to 65 years
• Scheduled for elective forearm fracture surgery
• Planned to receive either general anesthesia or infraclavicular brachial plexus block
• American Society of Anesthesiologists (ASA) physical status I-III
• Able to provide written and verbal informed consent

You may not qualify if…

• Age <18 years or >65 years
• Emergency surgery
• Refusal or inability to provide informed consent
• ASA physical status IV or V
• Known bone diseases or metabolic bone disorders
• Multiple trauma or associated organ injury
• Inability to mobilize
• Morbid obesity (BMI >40 kg/m²)
• Renal failure
• Hepatic failure
• Neurological deficits or sequelae
• Contraindication or allergy to any anesthetic agents used in the study

Full record on ClinicalTrials.gov

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