Comparison of Ultrasound Cerebral Perfusion Imaging With Routine Perfusion CT

Recruiting now · Not applicable

Conditions studied: Neuro ICU, Sub Arachnoid Hemorrhage, Neurological Complication, Cerebral Ischemia, Brain Injuries, Vascular

In brief

The primary goal of neurocritical care is to prevent secondary brain injury, which worsens neurological outcomes. Because clinical monitoring is often insufficient due to the patient's condition and medical treatments, multimodal monitoring using biophysical, electrophysiological, and imaging data is essential. In patients with subarachnoid hemorrhage (SAH), the most frequent and severe complication is delayed cerebral ischemia, often linked to arterial vasospasm and potentially leading to infarction. Early diagnosis combines transcranial Doppler (TCD), sensitive to vasospasm, with perfusion CT (CTP), which measures cerebral perfusion; this approach guides therapy and improves prognosis. Ultrasound, especially when enhanced with contrast agents (CEUS), allows non-invasive, bedside, repeated visualization of cerebral blood flow and perfusion-even through the skull. Agents like SonoVue® help quantify perfusion using time-intensity curves. The study aims to assess whether cerebral perfusion measurements from the SYLVER device are equivalent to those from CTP in ICU or CCU patients.

Key facts

Study ID: NCT07324421
Run by: Resolve Stroke
People needed: 50
Starts: 2025-10-25
Expected to finish: 2026-08-15
Last updated by the study team: 2026-01-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patient ≥ 18 years old
Patient Informed Consent, or from his/her relative if the patient is not conscious and able to consent
Admission to ICU or CCU with indication to perform at least one CTP
Affiliated with or benefiting from a social security scheme
The subject's current clinical status, as assessed by medical history, physical examination, and/or relevant tests, indicates that they do not require immediate medical treatment or emergency care at the time of enrolment.

You may not qualify if…

Guardianship, curatorship or any deprivation of liberty by judicial or administrative decision
Pregnant or breast-feeding women
Known contra-indication or hypersensitivity to SonoVue® (to sulfur hexafluoride microbubbles or to one of its excipients such as polyethylene glycol (PEG))
Right-to-left shunts
Patients who have undergone craniectomy in the temporal region
Patients with open wounds or recent scars in the temporal region
Unstable hemodynamic or respiratory state contraindicating transportation to CTP scanner

Where it is running

Centre Hospitalo-Universitaire Gui de Chauliac — Montpellier, Herault, France (enrolling)

Full record on ClinicalTrials.gov

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