SAS 1: Develop Ocular Disease (OSD) Diagnostic, Algorithms, and Management Protocols for Cataract Surgery
Recruiting now
Conditions studied: Dry Eye
In brief
Patient: Tear film issues resulting in poor visual outcomes are a major cause of dissatisfaction after cataract surgery. There is no universal best preoperative algorithm for managing the ocular surface prior to surgery. Industry: Recent advances in tear/cornea imaging and refractive cataract surgery such as multifocal intraocular lenses will be advantageous to patients only if tear film issues can be addressed. Society: Cataract surgery is the most common ophthalmic surgery done in Singapore and worldwide. Improving vision by attending to tear film problems improves quality of life.
Key facts
- Study ID
- NCT07323264
- Run by
- Louis Tong
- People needed
- 110
- Starts
- 2025-06-27
- Expected to finish
- 2027-10-31
- Last updated by the study team
- 2026-01-07
Who can join
Age: 21 and older, up to 99. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Inclusion criteria for dry eye (participant must meet at least 1 of the inclusion criteria below):
- Symptomatic for dry eye based on DEQ5 (>6) and [either TBUT less than 5 s or staining >grade 1 in any zone of the cornea]
- Either use of diquasfosol, cyclosporine eyedrops or tacrolimus eyedrops for dry eye disease in the last 2 weeks (and previously started for more than 2 months), OR current and visible lower punctal plugs in at least one eye
- Inclusion criteria to fulfil all for controls (patients w/o dry eye):
- DEQ5 <=6.
- Staining < grade 1 in at least one corneal zone.
- Not using diquasfosol, cyclosporine, tacrolimus in last 2 months.
- No visible punctal plugs.
You may not qualify if…
- If there is another ocular condition which affects vision as much as cataract: active corneal stromal disease or scar or significant corneal endothelial disease
- Known diagnosis of active thyroid dysfunction, Sjogren disease and rheumatoid arthritis
- Intraocular surgery within the previous 6 months
- Laser-assisted in situ keratomileusis or pterygium surgery within the previous 3 months
- Central nervous system and hormonal drugs required within the last month and during the study
- Active ocular infection, inflamed chalazion, or presence of pterygium
- Glaucoma which requires topical anti-glaucoma medications
- Any need to wear contact lens during the study
- Having issues which make it difficult to follow up (eg., wheelchair, etc)
- Pregnant and breast-feeding woman
Where it is running
- Singapore Eye Research Institute — Singapore, Singapore (enrolling)
Full record on ClinicalTrials.gov
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