Multi-modal Imaging of Myofascial Pain - Phase 2
Recruiting now · Not applicable
Conditions studied: Myofascial Pain
In brief
The goal of this study is to evaluate imaging biomarkers for quantitative assessments of myofascial pain and determine their ability to monitor treatment response and predict clinical outcomes.
Key facts
- Study ID
- NCT07322445
- Run by
- Washington University School of Medicine
- People needed
- 100
- Starts
- 2025-10-01
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2026-01-07
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults between the ages of 18 and 80 years old.
- History of spontaneous (non-provoked) pain in the neck and/or shoulder region lasting at least 3 months. Neck and/or shoulder pain, unilateral or bilateral.
- Presence of a palpable myofascial trigger point (MTrP) in one or both upper trapezius muscles.
- The participant has a Numeric Pain Rating Scale of 4/10 or more in the last one week, and the pain is reproducible by palpating the trigger point.
- Pain localized to the area of the trigger point that is reproduced or worsened upon palpation.
- Radiation of pain to the head, neck, or face with palpation is allowed but not required.
You may not qualify if…
- Age <18 or >80 years old.
- Acute cervical spine pathology, trauma (e.g. whiplash) or cervical radiculopathy
- History of surgery involving the head, neck, or shoulder girdle.
- Presence of neuromuscular pathologies or inflammatory muscle diseases (e.g. dermatomyositis)
- Systemic disease with diffuse body pain (e.g. system lupus erythematosus)
- Peripheral neuropathy
- Cancer-related pain
- Pregnancy, coagulopathy or other bleeding disorder, fever, general/local infection at the pain site, substance abuse, or any other diseases that may account for signs and symptoms mimicking myofascial pain.
- Contraindication to MRI
- Chronic fatigue syndrome, fibromyalgia, or chronic Lyme disease.
- Use of acupuncture or changes in pain medications within 6 weeks of enrollment.
- Receipt of Botox injection to the neck/shoulder region within the past 3 months or trigger point injection within the past 6 weeks.
Where it is running
- Washington University — St Louis, Missouri, United States (enrolling)
Full record on ClinicalTrials.gov
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