Hemodynamics During Cesarean Delivery Under Spinal Anesthesia With Norepinephrine Versus Ephedrine

Recruiting now · Phase 4

Conditions studied: Cesarean Delivery, Spinal Anesthesia for Cesarean Section

In brief

Echocardiography will be used to measure cardiac output and calculate other important hemodynamic variables in healthy patients with full-term singleton pregnancy during cesarean delivery under conventional spinal anesthesia using 2 different vasopressor drugs: norepinephrine in 1 group versus ephedrine in another group.

Key facts

Study ID

NCT07322419

Run by

Mansoura University

People needed

200

Starts

2026-01-01

Expected to finish

2026-12-31

Last updated by the study team

2026-01-14

Who can join

Age: 19 and older, up to 40. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• American Society of Anesthesiologists physical status II.
• Singleton, full term pregnancy.
• Scheduled cesarean delivery under spinal anesthesia.

You may not qualify if…

• Height <150 or >180 cm.
• Weight <60 or >110 kg.
• Body mass index (BMI) <18.5 or ≥35 kg/m².
• Women presenting in labor.
• Any contraindication to spinal anesthesia: increased intracranial pressure, coagulopathy, or local skin infection.
• Chronic or pregnancy-induced hypertension.
• Baseline systolic blood pressure >140 mm Hg.
• Hemoglobin <10 g/dl.
• Diabetes mellitus, cardiovascular, cerebrovascular, or renal disease.
• Polyhydramnios or known significant fetal abnormalities.
• Current administration of vasoactive drugs such as: beta blockers, salbutamol, or thyroxin.

Where it is running

• Department of Anesthesia and Surgical Critical Care, Mansoura University Hospitals — Al Mansurah, Dakahlia Governorate, Egypt (enrolling)

Full record on ClinicalTrials.gov

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