A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes

Recruiting now · Phase 3 · Has a placebo group

Conditions studied: Obesity, Overweight

In brief

The purpose of this study is to evaluate the efficacy and safety of eloralintide in adults with obesity or overweight who do not have type 2 diabetes. The study has two phases: a main phase and an extension phase. Participation in the main phase of the study will last about 75 weeks. Participants with prediabetes will continue in the extension phase for another 2 years.

Key facts

Study ID

NCT07321886

Run by

Eli Lilly and Company

People needed

1980

Starts

2026-02-06

Expected to finish

2030-07-01

Last updated by the study team

2026-08-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have Body Mass Index (BMI) at screening of the following:
• 30 kilogram per square meter (kg/m2) OR
• 27 kg/m2 with at least one of the following weight-related health conditions at screening:
• high blood pressure
• dyslipidemia
• obstructive sleep apnea, or
• heart disease
• Have a stable body weight (<5% body weight change) for 90 days prior to screening.
• Have a history of at least one self-reported unsuccessful dietary effort to reduce body weight

You may not qualify if…

• Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed >1 year before screening)
• Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
• Have type 1 diabetes or type 2 diabetes
• Have had within 90 days prior to screening:
• heart attack
• stroke
• coronary artery revascularization
• unstable angina, or
• hospitalization due to congestive heart failure
• Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
• Have taken medications or alternative remedies intended for weight loss within 90 days of screening

Where it is running

• Headlands Research - Scottsdale — Scottsdale, Arizona, United States (enrolling)
• Neighborhood Healthcare Institute of Health — Escondido, California, United States (enrolling)
• Ark Clinical Research - Fountain Valley — Fountain Valley, California, United States (enrolling)
• Desert Oasis Healthcare Medical Group — Palm Springs, California, United States (enrolling)
• Peninsula Research Associates — Rolling Hills Estates, California, United States (enrolling)
• Care Access - Sacramento — Sacramento, California, United States (enrolling)
• Southern California Clinical Research — Santa Ana, California, United States (enrolling)
• University Clinical Investigators, Inc. — Tustin, California, United States (enrolling)
• Chase Medical Research, LLC — Waterbury, Connecticut, United States (enrolling)
• JEM Research Institute — Atlantis, Florida, United States (enrolling)
• BioMed Research & Medical Center — Miami, Florida, United States (enrolling)
• Adult Medicine of Lake County, Inc. — Mt. Dora, Florida, United States (enrolling)
• American Research Centers of Florida — Pembroke Pines, Florida, United States (enrolling)
• AHF Pensacola — Pensacola, Florida, United States (enrolling)
• IMA Clinical Research St. Petersburg — St. Petersburg, Florida, United States (enrolling)
• Teak Research Consults - Dunwoody — Dunwoody, Georgia, United States (enrolling)
• Teak Research Consults — Lawrenceville, Georgia, United States (enrolling)
• Clinical Research Atlanta — Stockbridge, Georgia, United States (enrolling)
• East-West Medical Research Institute — Honolulu, Hawaii, United States (enrolling)
• Iowa Diabetes and Endocrinology Research Center — West Des Moines, Iowa, United States (enrolling)
• Cotton O'Neil Clinical Research Center — Topeka, Kansas, United States (enrolling)
• Care Access - Lake Charles (Bayou Pines) — Lake Charles, Louisiana, United States (enrolling)
• MedStar Good Samaritan Hospital — Baltimore, Maryland, United States (enrolling)
• MedStar Health Research Institute (MedStar Physician Based Research Network) — Hyattsville, Maryland, United States (enrolling)
• MFA Clinical Research — Tuscaloosa, Alabama, United States (enrolling)

Full record on ClinicalTrials.gov

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