The Effect of Exercise Training on lncRNA Expression in Rheumatoid Arthritis

Recruiting now · Not applicable

Conditions studied: Exercise, Pulmonary Rehabilitation, Interstitial Lung Disease, Long Noncoding RNA, Inspiratory Muscle Training, Rheumatoid Arthritis

In brief

The goal of this observational study is to examine the effects of traditional respiratory rehabilitation and respiratory muscle strengthening training added to this program at the genetic level in in patients with rheumatoid arthritis-associated interstitial lung disease. The main questions it aims to answer are: * Does respiratory muscle strengthening exercise added to respiratory rehabilitation in patients with rheumatoid arthritis-associated interstitial lung disease have additional benefits on rehabilitation outcome measures such as exercise capacity, shortness of breath, and muscle strength? * Does the gain obtained with respiratory muscle strengthening iin patients with rheumatoid arthritis-associated interstitial lung disease increase the quality of life of patients and have a positive effect on their psychological state? * Does respiratory rehabilitation applied to iin patients with rheumatoid arthritis-associated interstitial lung disease have an effect on genetic changes? * Does respiratory muscle strengthening training applied in addition to respiratory rehabilitation in patients with rheumatoid arthritis-associated interstitial lung disease have an effect on genetic changes? * Participants will be included in two different respiratory rehabilitation programs with and without respiratory muscle training, and pre- and post- treatment rehabilitation criteria and genetic changes will be compared.

Key facts

Study ID

NCT07320846

Run by

Saglik Bilimleri Universitesi

People needed

39

Starts

2024-05-18

Expected to finish

2026-03-12

Last updated by the study team

2026-01-06

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Diagnosed with RA according to the ACR/EULAR 2010 classification criteria
• Duration of diagnosis greater than 2 years
• Disease activity with a DAS28 score below 5.1
• Voluntary participation in the study
• Presence of lung involvement

You may not qualify if…

• Having orthopedic deformities that may affect the treatment program
• Pregnancy
• Uncontrolled diabetes or heart disease
• Participation in a rehabilitation program within the last 6 months
• Body Mass Index (BMI) > 30
• Patients with severe organ failure
• Recent acute coronary syndrome
• Presence of active infection

Where it is running

• University of Health Sciences — Istanbul, Turkey, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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