Cognitive Rehabilitation for Veterans With PNES
Recruiting now · Not applicable
Conditions studied: Psychogenic Nonepileptic Seizures (PNES)
In brief
Psychogenic nonepileptic seizures (PNES) reflect a subtype of functional neurological disorder (FND) that is common and extremely disabling in Veterans. Cognitive problems are highly prevalent in PNES, they reduce quality of life, and they severely limit daily functioning. Currently, there are no available treatments that target cognition to improve daily function in PNES or other FNDs, leaving a major gap in the literature. Cognitive re-habilitation improves daily functioning in Veterans with related neuropsychiatric disorders and has a high chance of success in Veterans with PNES. The proposed study will solicit direct input from Veterans with PNES via qualitative interviews to inform the design of a cognitive treatment workbook. The workbook will then be iteratively refined based on participatory feedback from Veterans with PNES and their treatment providers. The full cognitive intervention protocol will be pilot tested to inform a fully powered RCT. Results will support a line of research that aims to improve cognition and function in Veterans with PNES and related FNDs.
Key facts
- Study ID
- NCT07316543
- Run by
- VA Office of Research and Development
- People needed
- 47
- Starts
- 2026-03-02
- Expected to finish
- 2031-07-01
- Last updated by the study team
- 2026-03-12
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- U.S. Veteran
- able to provide informed consent
- reports cognitive difficulties
- prior video EEG diagnosis of PNES
- English speaking
- able to read at least at 8th grade level
- access to a private space with a computer (13-inch monitor)
- internet access
You may not qualify if…
- acute psychosis (hallucinations or delusions)
- current active suicidality
- a diagnosis of dementia or intellectual disability
- sensory impairment (e.g., deafness) that would preclude participation
Where it is running
- Providence VA Medical Center, Providence, RI — Providence, Rhode Island, United States (enrolling)
Full record on ClinicalTrials.gov
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