Antimicrobial Photodynamic Therapy With ICG-Loaded Nanoparticles for Periodontitis Management
Recruiting now · Phase 2
Conditions studied: Stage III Periodontitis
In brief
To better understand and treat your gum disease, dentists now use a system that stages its severity and grades its speed, rather than using old labels. The recommended first step is almost always a deep cleaning, which is very effective. However, because some bacteria can hide from cleanings and antibiotics, researchers are exploring a promising light-based treatment. This method uses a safe, light-activated dye and a gentle laser to target and kill bacteria without leading to resistance. To make this treatment even stronger, scientists are testing a way to package the dye inside tiny, biodegradable "containers" that deliver it directly to the germs. The goal of this research is to see if this advanced delivery method works better than the dye alone, hoping to provide a more powerful, non-surgical option to fight gum disease and protect your teeth."
Key facts
- Study ID
- NCT07316023
- Run by
- Nada Mahmoud Soliman
- People needed
- 27
- Starts
- 2026-01-15
- Expected to finish
- 2026-08-30
- Last updated by the study team
- 2026-01-05
Who can join
Age: 36 and older, up to 50. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 1- Both genders aged between 36-50 years (Wadhwa et al., 2021) 2- Generalized stage III grade B periodontitis (Papapanou et al., 2018). Posterior teeth, stage III with PD>6 mm and CAL ≥5 mm 3- Patients ready to comply with oral hygiene measures. 4- Patients free from any systemic disease that may affect the treatment (Glick et al., 2008)
You may not qualify if…
- Exclusion criteria:
- Smokers
- Pregnant females.
- Drug abusers.
- Patients taking antibiotics or performed any periodontal treatment in the previous 6 months.
- Justification for Exclusions:
- To reduce any confounding factors and bias that may affect the results of this study.
Where it is running
- Faculty of Dentistry , Ainshams University — Cairo, Egypt (enrolling)
Full record on ClinicalTrials.gov
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