Using Artificial Intelligence to Guide Fluid Therapy During Major Cancer Surgery: A Randomized Controlled Trial

Starting soon · Not applicable

Conditions studied: Neoplasm, Cancer, Hemodynamic (MAP) Stability, Cancer Surgery, Artificial Intelligence (AI), Fluid Therapy DURING SURGERY

In brief

The goal of this clinical trial is to learn if using artificial intelligence to guide intravenous fluid therapy during major cancer surgery can help keep blood pressure more stable compared with usual care in adult patients undergoing major cancer surgery. The main questions it aims to answer are: * Does artificial intelligence-guided fluid therapy reduce hypotensive events during surgery? * Does this approach improve recovery and reduce complications after major cancer surgery? Researchers will compare artificial intelligence-guided fluid therapy with standard fluid management to see if the artificial intelligence-guided approach provides better support during surgery. Participants will: * Undergo major cancer surgery under general anesthesia * Receive either artificial intelligence-guided fluid management or standard fluid management during surgery * Be monitored during and after surgery as part of routine clinical care * Be followed after surgery to assess recovery and possible complications

Key facts

Study ID

NCT07314853

Run by

National Cancer Institute, Naples

People needed

176

Starts

2026-02-01

Expected to finish

2029-02-01

Last updated by the study team

2026-01-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• American Society of Anesthesiologists (ASA) Physical Status II-IV
• Undergoing major abdominal oncologic surgery (open or laparoscopic) with an expected duration >2 hours
• Planned invasive arterial pressure monitoring
• Ability to understand and sign informed consent

You may not qualify if…

• Significant arrhythmias (e.g., persistent atrial fibrillation)
• Severe aortic stenosis
• Emergency surgery
• Sepsis
• End-stage renal disease on dialysis
• Pregnancy
• Impossibility to cannulate the radial artery
• Refusal to participate or refusal of data processing consent

Where it is running

• IRCCS Istituto Nazionale Tumori "Fondazione G. Pascale" — Naples, Italy

Full record on ClinicalTrials.gov

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