Drug-drug Interaction Study of Bemnifosbuvir/Ruzasvir (BEM/RZR) and Buprenorphine/Naloxone or Methadone

Recruiting now · Phase 1

Conditions studied: Healthy Volunteer Study

In brief

Drug-drug interaction study between Bemnifosbuvir/Ruzasvir (BEM/RZR) and Buprenorphine/Naloxone or Methadone

Key facts

Study ID

NCT07314346

Run by

Atea Pharmaceuticals, Inc.

People needed

32

Starts

2025-01-07

Expected to finish

2026-08-01

Last updated by the study team

2026-07-16

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Must agree to use acceptable contraceptive methods through at least 90 days after the last dose of study drug.
• Minimum body weight of 50 kg and body mass index (BMI) of 18-32 kg/ m2.
• Willing to comply with the study requirements and to provide written informed consent.

You may not qualify if…

• Infected with hepatitis B virus, hepatitis C virus, HIV.
• Abuse of alcohol or drugs.
• Use of other investigational drugs within 28 days prior to Day -5.
• Concomitant use of prescription medications, or systemic over-the-counter medications (apart from methadone or buprenorphine/naloxone as assigned maintenance therapy).
• Other clinically significant medical conditions or laboratory abnormalities.

Where it is running

• Atea Study Site — Hollywood, Florida, United States (enrolling)
• Atea Study Site — Overland Park, Kansas, United States (enrolling)
• Atea Study Site — Marlton, New Jersey, United States (enrolling)

Full record on ClinicalTrials.gov

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