A Trial to Assess How Centanafadine Interacts With Stimulants in the Body

Completed · Phase 1

Conditions studied: ADHD

In brief

This study will look at how centanafadine works when taken together with stimulant medicines in healthy adults, and whether combining them affects how the body responds.

Key facts

Study ID

NCT07314333

Run by

Otsuka Pharmaceutical Development & Commercialization, Inc.

People needed

40

Starts

2026-02-05

Expected to finish

2026-04-15

Last updated by the study team

2026-05-05

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Body mass index (BMI) between 18.0 to 32.0 kilogram per square meter (kg/m2).
• Must be in good health, based on:
• Medical history
• Physical examination
• Heart test (Electrocardiogram [ECG])
• Lab tests (blood, urine and other routine checks)
• Willing to stay in the clinic for the required time and agree to a follow-up phone call for safety.
• Able to sign informed consent and, in the investigator's opinion, follow all trial requirements.

You may not qualify if…

• History of drug and/or alcohol abuse in past 2 years.
• History of or current hepatitis or acquired immune deficiency syndrome (AIDS) or carriers of hepatitis B surface antigen (HBsAg) and/or anti-hepatitis C virus (HCV), or human immunodeficiency virus (HIV) antibodies.
• Known drug allergy or hypersensitivity.
• Any history of significant bleeding problems.
• Difficulty donating blood in the past.
• Use of tobacco or exposure to second-hand smoke in the past 2 months, or high cotinine levels in blood/urine.
• Uncontrolled high blood pressure (BP) (systolic blood pressure [SBP] > 140 millimeters of mercury (mmHg) or diastolic blood pressure [DBP] > 90 mmHg) or symptomatic low blood pressure, or orthostatic hypotension (large BP drop when standing).
• History of unexplained fainting (syncope).
• Serious mental health disorders that could interfere with participation.

Where it is running

• ICON — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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