Mode of Ventilation During Critical Illness at Multiple Centers
Enrolling by invitation · Not applicable
Conditions studied: Respiratory Failure, Mechanical Ventilation, Critical Illness
In brief
The goal of this clinical trial is to learn whether the choice of ventilator mode for patients on breathing machines in the intensive care unit affects their survival and recovery. To do this, researchers will assign the entire participating intensive care unit to one of the three available ventilator modes, alternating which mode is assigned in random sequence every 2 months. The main question it aims to answer is: Does the choice between volume control, pressure control, and adaptive pressure control affect the number of days that patients are alive and free of the breathing machine?
Key facts
- Study ID
- NCT07313956
- Run by
- Vanderbilt University Medical Center
- People needed
- 4785
- Starts
- 2026-05-01
- Expected to finish
- 2030-03-01
- Last updated by the study team
- 2026-05-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patient is receiving mechanical ventilation through an endotracheal tube or tracheostomy
- Patient is physically located in a participating adult ICU
You may not qualify if…
- Patient is known to be less than 18 years old
- Patient is known to be a prisoner
- Patient is known to have been receiving invasive mechanical ventilation at place of residence prior to hospital admission
- Patient is receiving extracorporeal membrane oxygenation at the time when inclusion criteria are first met
Where it is running
- Rush University Medical Center — Chicago, Illinois, United States
- The Johns Hopkins Hospital — Baltimore, Maryland, United States
- Wake Forest University Health Sciences — Winston-Salem, North Carolina, United States
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
Full record on ClinicalTrials.gov
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