Efficacy of Clonidine in Reducing Craving in Inpatients With Cocaine and Crack Use Disorder

Recruiting now · Phase 4

Conditions studied: Cocaine Use Disorder, Crack Abuse or Dependence

In brief

This is a single-center, randomized intervention study in a volunteer population of patients with cocaine/crack use disorder to evaluate the pharmacological treatment of cocaine/crack craving, comparing the drug clonidine with the active placebo clonazepam.

Key facts

Study ID

NCT07313371

Run by

University of Sao Paulo General Hospital

People needed

36

Starts

2026-01-28

Expected to finish

2027-07-01

Last updated by the study team

2026-02-24

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients hospitalized in the adult Alcohol and Drugs ward of the Perdizes Institute (IPer) at the Hospital das Clínicas, University of São Paulo Medical School
• DSM-5 criteria for cocaine and/or crack use disorder
• Voluntarily seeking treatment
• Must be able to swallow pills

You may not qualify if…

• Inability to read and/or understand the study questionnaires
• benzodiazepine use disorder
• opioid use disorder
• alcohol use disorder

Where it is running

• Instituto Perdizes — São Paulo, São Paulo, Brazil (enrolling)

Full record on ClinicalTrials.gov

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