Predicting the Pain Outcome of Surgery for Endometriosis

Recruiting now

Conditions studied: Endometriosis

In brief

This study aims to determine whether the investigators can predict who will get benefit in terms of their pain from surgery for more severe forms of endometriosis. The investigators will use brain imaging to explore this, as it allows meaningful results from a smaller sample of people than if questionnaires alone were relied on.

Key facts

Study ID

NCT07313345

Run by

University of Oxford

People needed

100

Starts

2025-12-01

Expected to finish

2028-08-01

Last updated by the study team

2025-12-31

Who can join

Age: 18 and older, up to 50. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• willing and able to give informed consent
• aged between 18 and 50 years of age
• female or born female
• diagnosed with stage III or IV endometriosis by scan (MRI or USS) or previous surgery
• surgical treatment of severe endometriosis planned (surgical procedure at discretion of operating surgeon)
• reports pelvic pain of ≥4/10 (measured using a 0 - 10 numerical rating scale asking about the participant's worst pelvic pain associated with their endometriosis)
• reasonably fluent in English
• in the Investigator's opinion, is able and willing to comply with all study requirements
• willing to allow his or her General Practitioner and consultant to be notified of participation in the study

You may not qualify if…

• pregnant, lactating or planning pregnancy during the course of the study
• contraindication to MRI

Where it is running

• Oxford University Hospitals Foundation Trust — Oxford, Oxfordshire, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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