Study to Enable New Diagnostics for Pulmonary Microbes in People With CF
Recruiting now
Conditions studied: Cystic Fibrosis (CF), New Diagnostics
In brief
Sputum culture has been the best approach to detect harmful bacteria in the lungs of people with cystic fibrosis (CF). With the widespread use of new CF therapies (like Trikafta and Alyftrak), it is more difficult for people with CF to produce sputum even though they still have harmful bacteria in their lungs. The SEND-CF study is being done to see if there are other ways to detect harmful bacteria in the lungs.
Key facts
- Study ID
- NCT07312734
- Run by
- Chris Goss
- People needed
- 300
- Starts
- 2026-03-30
- Expected to finish
- 2027-08-01
- Last updated by the study team
- 2026-07-02
Who can join
Age: 16 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- ≥ 16 years of age on day of study visit
- Documentation of CF Diagnosis
- Able to expectorate sputum
- Percent predicted FEV1 ≥ 30%
You may not qualify if…
- History of solid organ transplantation
- History of active malignancy (or treatment for malignancy) in 12 months prior to the study visit
- Pregnant
Where it is running
- University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States (enrolling)
- University of Texas Southwestern — Dallas, Texas, United States (enrolling)
- Froedtert & Medical College of Wisconsin — Milwaukee, Wisconsin, United States (enrolling)
- The Minnesota Cystic Fibrosis Center — Minneapolis, Minnesota, United States (enrolling)
- Washington University School of Medicine — St Louis, Missouri, United States (enrolling)
- University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)
- Nationwide Children's Hospital — Columbus, Ohio, United States
- University of Nebraska Medical Center — Omaha, Nebraska, United States
- University of California San Diego — La Jolla, California, United States
Full record on ClinicalTrials.gov
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