A Prospective Longitudinal Observational Cohort Study of Pregnant Women Residing at High Altitude in Bolivia

Recruiting now

Conditions studied: Hypertensive Disorder of Pregnancy, Pulmonary Arterial Hypertension, Intrauterine Growth Restriction

In brief

In this study, the investigators will follow two small cohorts of pregnant women: a cohort of healthy women with uncomplicated pregnancies residing at high altitude, a control group of healthy women with uncomplicated pregnancies residing at sea level, to characterize differences in cardiopulmonary adaptation and nitric oxide (NO) pathway expression at elevations \>3,500 m throughout pregnancy and into the postpartum period. The investigators aim to investigate right-sided cardiac impairment induced by chronic hypobaric hypoxemia, its effects on fetal growth, and the potential contribution of cardiovascular nitric oxide depletion to obstetric complications.

Key facts

Study ID

NCT07312227

Run by

Massachusetts General Hospital

People needed

27

Starts

2026-02-11

Expected to finish

2027-02-01

Last updated by the study team

2026-05-26

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• women delivering at participating hospitals at more than 3500 meters or women delivering at participating hospitals at sea level
• signed informed consent

You may not qualify if…

• preexisting cardiopulmonary pathologies (CHD, COPD, CKD, NYHA > III)

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)
• Hospital De La Meujer — La Paz, Bolivia

Full record on ClinicalTrials.gov

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