HALP Score, Blood-Based Inflammatory Indices, and Salivary MMP-8 in Periodontal Disease and Healing After Non-Surgical Therapy

Recruiting now

Conditions studied: Periodontal Diseases, Periodontitis, Gingivitis; Chronic

In brief

This observational clinical study aims to investigate the relationship between the HALP score (Hemoglobin × Albumin × Lymphocyte / Platelet), several blood-based inflammatory indices (including NLR, PLR, LMR, and SII), and salivary MMP-8 levels in individuals with periodontal health, gingivitis, and stage III/IV periodontitis. The study also evaluates how these biomarkers relate to healing following non-surgical periodontal therapy. A total of 180 participants aged 18-65 years will be included: 50 healthy individuals, 50 patients with gingivitis, and 80 patients with stage III/IV periodontitis. All participants will undergo periodontal clinical examination and provide blood and saliva samples at baseline. Individuals in the gingivitis and periodontitis groups will receive standard non-surgical periodontal treatment (full-mouth debridement) and will return for a 3-month follow-up visit, where periodontal measurements will be repeated. In the periodontitis group, an additional blood sample will be collected at the 3-month follow-up visit. The primary objective is to determine whether baseline HALP score, systemic inflammatory indices, and salivary MMP-8 levels differ between participants who show good versus poor healing after treatment. Secondary objective include comparing biomarker levels across periodontal status groups. The findings may contribute to early prediction of treatment response and personalized periodontal care.

Key facts

Study ID

NCT07312045

Run by

Ömer Faruk Okumuş

People needed

180

Starts

2025-11-25

Expected to finish

2026-11-25

Last updated by the study team

2025-12-31

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults aged 18-65 years
• Ability to provide informed consent
• No systemic diseases or conditions affecting periodontal status
• For Healthy Group: Probing depth ≤3 mm, no attachment loss, no radiographic bone loss
• For Gingivitis Group: Gingival inflammation and bleeding on probing without attachment loss or bone loss
• For Periodontitis Group: Stage III or stage IV periodontitis according to 2018 classification
• No periodontal treatment within the past 6 months
• Willingness to attend follow-up visits

You may not qualify if…

• Systemic diseases influencing periodontal inflammation (e.g., diabetes, autoimmune disorders)
• Current pregnancy or lactation
• Use of antibiotics, anti-inflammatory medications, or immunosuppressive drugs within the last 3 months
• Smokers or individuals using tobacco products
• History of periodontal surgery in the last 6 months
• Presence of fewer than 20 natural teeth
• Any condition that may interfere with study participation or data reliability

Where it is running

• Erzincan Binali Yıldırım University Faculty of Dentistry — Merkez, Erzincan, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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