External Validation of the CLOVER Score for Detecting Occult Cancer in Venous Thromboembolism Patients

Recruiting now

Conditions studied: Venous Thromboembolism (VTE), Occult Cancer

In brief

This study aims to externally validate the CLOVER score, a machine learning-based predictive model designed to identify patients with venous thromboembolism (VTE) who are at increased risk of having an occult cancer. The study includes a retrospective cohort of patients with acute symptomatic VTE diagnosed between 2000 and 2022, and a prospective cohort of consecutively recruited patients from December 2025 to December 2027. The CLOVER model will be applied to all participants, and its ability to discriminate between patients with and without occult cancer will be evaluated. The study also assesses clinicians' satisfaction with the web-based tool (CLOVER-Web) developed to facilitate the use of the score in clinical practice.

Key facts

Study ID

NCT07310693

Run by

Infanta Leonor University Hospital

People needed

500

Starts

2025-12-01

Expected to finish

2028-12-31

Last updated by the study team

2025-12-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years.
• Objectively confirmed acute symptomatic venous thromboembolism (deep vein thrombosis and/or pulmonary embolism).
• Ability to provide written or electronic informed consent.

You may not qualify if…

• Suspicion of cancer during the initial diagnostic evaluation for VTE.
• Participation in another interventional study that may interfere with outcomes.
• Inability or refusal to provide informed consent.

Where it is running

• Hospital Clínic — Barcelona, Barcelona, Spain (enrolling)
• Hospital Universitario Infanta Leonor — Madrid, Madrid, Spain (enrolling)
• Hospital Universitario La Paz — Madrid, Madrid, Spain (enrolling)
• Hospital Universitario Príncipe de Asturias — Madrid, Madrid, Spain (enrolling)
• Hospital Universitatio del Sureste — Madrid, Madrid, Spain (enrolling)
• Hospital Universitario de Móstoles — Madrid, Madrid, Spain (enrolling)
• Hospital Clínico Universitario Virgen de la Arrixaca — Murcia, Murcia, Spain (enrolling)
• Hospital Universitario Morales Meseguer — Murcia, Murcia, Spain (enrolling)
• Hospital San Agustín — Avilés, Principality of Asturias, Spain (enrolling)
• Hospital Universitario Son Llatzer — Balea, Spain (enrolling)
• Hospital Universitario 12 de Octubre — Madrid, Spain (enrolling)
• Hospital Universitario de Fuenlabrada — Madrid, Spain (enrolling)

Full record on ClinicalTrials.gov

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