Creatine and Perioperative Brain Health

Starting soon · Not applicable · Has a placebo group

Conditions studied: Neurocognitive Disorders, Postoperative Delirium

In brief

The overall goal of this study is to evaluate the feasibility of perioperative oral creatine supplementation and to explore its effects on cognitive function and physiological responses to surgery in older adults. Creatine is commonly used to enhance athletic performance, but it can also have positive effects on the brain. Since surgery can alter thinking, memory, and attention patterns in some patients, we will assess whether creatine affects these changes in older adults undergoing surgery.

Key facts

Study ID

NCT07310043

Run by

Massachusetts General Hospital

People needed

120

Starts

2026-09-01

Expected to finish

2028-08-30

Last updated by the study team

2026-08-10

Who can join

Age: 60 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients scheduled for elective surgery under general anesthesia

You may not qualify if…

• History of creatine deficiency disorders
• Renal or neurodegenerative disorders
• History of stroke or significant head trauma, presence of intracranial mass lesions
• Inability to give informed consent

Full record on ClinicalTrials.gov

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