Postoperative Hypoxemia Increases the Risk of Anastomotic Leak After Radical Esophagectomy
Recruiting now
Conditions studied: Esophageal Carcinoma, Esophageal Adenocarcinoma, Esophagectomy, PaO2, Esophageal Anastomotic Leakeage
In brief
This study aims to determine whether postoperative hypoxia (arterial partial pressure of oxygen (PaO₂)\<80 mmHg) is an independent risk factor for anastomotic leakage after esophagectomy. The investigators conducted a retrospective analysis of cases from their center over the past five years, stratifying patients into Low Pa0₂ Group and Normal Pa0₂ Group based on postoperative oxygen levels and comparing the incidence of anastomotic leakage between the groups. The goal is to establish whether hypoxia is a causative risk factor and whether correcting it can reduce the risk of anastomotic leakage.
Key facts
- Study ID
- NCT07309991
- Run by
- Sun Yat-sen University
- People needed
- 2500
- Starts
- 2021-01-01
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2026-06-16
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients diagnosed with esophageal carcinoma or benign esophageal tumors
- Patients requiring surgical resection of the lesion with subsequent esophageal reconstruction
- Patients must have had at least one postoperative arterial blood gas analysis
- Patients must have routinely undergone at least one of the following for postoperative evaluation of the anastomosis: endoscopy, CT scan, or esophagram
You may not qualify if…
- Patients who did not require esophageal reconstruction
- Patients undergoing esophageal replacement with colon
- Patients with incomplete data
Where it is running
- Department of Thoracic Surgery, Sun Yat-sen University Cancer Center — Guangzhou, Guangdong, China (enrolling)
- Cancer Hospital of Shantou University Medical College — Shantou, Guangdong, China (enrolling)
- The Fourth Hospital of Hebei Medical University and Hebei Tumor Hospital — Shijiazhuang, Hebei, China (enrolling)
- Shanghai Chest Hospital — Shanghai, Shanghai Municipality, China (enrolling)
- Sichuan Cancer Hospital — Chengdu, Sichuan, China (enrolling)
- 0817-2598459 — Nanchong, Sichuan, China (enrolling)
Full record on ClinicalTrials.gov
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