MPR for Stroke Risk Assessment of ICAS

Recruiting now

Conditions studied: ICAS - Intracranial Atherosclerosis, Stroke Ischemic, Hemodynamic

In brief

Intracranial atherosclerotic stenosis (ICAS) carries substantial stroke risk despite optimal medical treatment. Current risk stratification relies primarily on stenosis severity, but novel hemodynamic markers may improve prediction. In this multiple prospective registry study we aim to investigate whether regional hemodynamics, measured by a novel Magnetic resonance imaging-derived Pressure Ratio (MPR) technique, are associated with stroke risk in ICAS.

Key facts

Study ID: NCT07309718
Run by: Xuanwu Hospital, Beijing
People needed: 400
Starts: 2025-12-01
Expected to finish: 2028-03-31
Last updated by the study team: 2025-12-30

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Adults aged 18 to 80 years.
Intracranial atherosclerotic stenosis ICAS involving a culprit artery in the anterior circulation.
Intracranial arterial stenosis of 50% to 99% as measured by the WASID method using TCD, CTA, MRA, or DSA.
Written informed consent obtained from the participant or a legal representative.

You may not qualify if…

Non-atherosclerotic intracranial lesions, including moyamoya disease, vasculitis, vascular dissection, autoimmune diseases, or congenital/genetic abnormalities.
More than 50% stenosis of the extracranial carotid artery on the ipsilateral side.
Large cerebral infarction involving more than one-half of the territory on DWI imaging, or a baseline modified Rankin Scale score ≥3.
Contraindications to antiplatelet therapy or statins.
Inability to undergo MRI due to metal implants or claustrophobia.

Where it is running

Department of Neurosurgery, Xuanwu hospital — Beijing, Xicheng District, China (enrolling)

Full record on ClinicalTrials.gov

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