Sucrase-Isomaltase (SI) Genes and Meal Load

Recruiting now · Not applicable

Conditions studied: IBS - Irritable Bowel Syndrome, Sucrase-Isomaltase Deficiency

In brief

The goal of this interventional study is to examine whether those patients with irritable bowel syndrome (IBS) and a reduced abitility do degrade starch and sugar (lowe levels of enzymes) have lower raise in blood glucose after a meal than those with normal expression of enzymes. We also want to examine whether those IBS patients with reduced enzyme levels have increased bowel symptom in relation to this meal. The main questions it aims to answer are: Does reduced ability to degrade starch and sugar due to less enzyme activity lead to lower increase in blood glucose after a meal? Does reduced ability to degrade starch and sugar due to less enzyme activity lead to increased bowel symptoms after a meal?

Key facts

Study ID: NCT07309601
Run by: Region Skane
People needed: 70
Starts: 2026-02-01
Expected to finish: 2030-02-01
Last updated by the study team: 2026-04-29

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Diagnosis of irritable bowel syndrome (IBS)
Gene testing has been conducted regarding genes regulating the production of sucrase-isomaltase ensymes in previous dietary interventions using the starch- and sucrose reduced diet (SSRD) or multi-center study.

You may not qualify if…

Diagnosis of inflammatory bowel disease, celiac disease, bile salt malabsorption, gastroenteritis or enteric dysmotility
Severe food allergy
Serious heart-, lung-, cardiovascular-, malignant- or mental illness
Ongoing eating disorder
Pregnancy
Recent major gastrointestinal surgery
Alcohol and/or drug addiction

Where it is running

Skåne University Hospital — Malmö, Skåne County, Sweden (enrolling)

Full record on ClinicalTrials.gov

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