Pharmacokinetics of Didehydro-LSD (DDH-LSD) Compared With LSD
Recruiting now · Not applicable · Has a placebo group
Conditions studied: LSD Reaction
In brief
This study investigates DDH-LSD, a novel LSD-like compound expected to have a shorter duration of action than LSD. In healthy volunteers, pharmacokinetics, safety, and subjective effects, will be assessed and compare with LSD in a controlled cross-over study.
Key facts
- Study ID
- NCT07309471
- Run by
- University Hospital, Basel, Switzerland
- People needed
- 24
- Starts
- 2026-03-06
- Expected to finish
- 2028-07-01
- Last updated by the study team
- 2026-03-10
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age between 25 and 65 years old
- Sufficient understanding of the German language
- Understanding of procedures and risks associated with the study
- Willing to adhere to the protocol and signing of the consent form
- Willing to refrain from the consumption of illicit psychoactive substances during the study
- Abstaining from xanthine-based liquids from the evenings prior to the study sessions and during the sessions
- Willing not to operate heavy machinery within 48 h of substance administration
- Willing to use effective contraceptive measures throughout study participation
- Body mass index between 18-32 kg/m2
You may not qualify if…
- Chronic or acute medical condition
- Current or previous major psychiatric disorder
- Psychotic disorder or bipolar disorder in first-degree relatives
- Hypertension (SBP>140/90 mmHg) or hypotension (SBP<85 mmHg)
- Use of hallucinogenic substances (not including cannabis) more than 20 times or any time within the previous two months
- Pregnancy or currently breastfeeding
- Participation in another clinical trial (currently or within the last 30 days)
- Use of medication that may interfere with the effects of the study medication
- Tobacco smoking (>10 cigarettes/day)
- Consumption of alcoholic beverages (>20 drinks/week)
Where it is running
- University Hospital Basel — Basel, Switzerland (enrolling)
Full record on ClinicalTrials.gov
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