Impact of Cannabis Consumption on Psychotic Symptoms and Reality Monitoring in Patients With Schizophrenia: a Real-life Study

Starting soon · Phase 1/Phase 2

Conditions studied: Schizophrenia

In brief

This study aims to examine the dual effects of cannabis consumption on both positive and negative symptoms of schizophrenia, across laboratory and real-world contexts. By integrating ecological momentary assessment (EMA) with cognitive tasks such as reality monitoring, the research seeks to clarify how cannabis use influences symptom severity and cognitive functioning in individuals with schizophrenia. Gaining insight into these relationships may contribute to the development of more effective management strategies and ultimately improve outcomes for patients living with schizophrenia.

Key facts

Study ID

NCT07309159

Run by

Centre Hospitalier Charles Perrens, Bordeaux

People needed

120

Starts

2026-06-01

Expected to finish

2028-12-31

Last updated by the study team

2026-03-16

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• DSM-5 diagnosis of schizophrenia or schizo-affective disorder with the following clinical features:
• Clinically stable and in the residual (non-acute) phase of illness,
• No change in antipsychotic treatment for at least 1 month,
• Outpatient, ambulatory care,
• No uncontrolled positive symptoms (assessed using PANSS)
• Patients able to use a mobile phone.
• Capacity and willingness to give informed consent.
• Must be able to read, speak, and understand French
• Patients subscribing to the French national medical insurance.
• Patients under "curatelle" (partial guardianship) are eligible

You may not qualify if…

• Patient under "tutelle" (full legal guardianship).
• Psychiatric comorbidities: autism, bipolar disorder.
• Current criteria for any other substance use disorder except for nicotine use disorder.
• Any medical condition hindering the study and/or use of the smartphone application.
• Patients with somatic, cognitive or other disorders preventing the use of the device (deafness, impaired vision, illiteracy….).
• Pregnant or breastfeeding woman.
• Patients who are not proficient in French.
• Subject included in clinical and/or therapeutic experimentation in progress.

Full record on ClinicalTrials.gov

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