Local Field Potentials in Dystonia
Recruiting now
Conditions studied: Dystonia, Dystonia, Focal, Dystonia, Primary
In brief
The goal of this clinical trial is to learn whether local field potential (LFP) signals recorded from the globus pallidus interna (GPi) using the Medtronic Percept™ deep brain stimulation (DBS) device can help optimize DBS programming for people with dystonia. The study will also explore whether LFP patterns can serve as a biomarker of disease activity and predict treatment response. The main questions it aims to answer are: Do LFP peaks in the alpha-theta range reliably correlate with dystonia severity and clinical characteristics? Can LFP-based programming achieve similar or better clinical outcomes compared to traditional programming methods? How do LFP profiles change with stimulation and other treatments such as botulinum toxin or oral medications? Researchers will compare two programming approaches: Traditional programming based on clinical assessment and imaging. LFP-guided programming based on the site and characteristics of LFP peaks Participants will: Undergo DBS surgery for dystonia as part of standard clinical care. Attend regular follow-up visits for DBS programming and outcome assessments. Complete clinical rating scales for dystonia severity, quality of life, cognition, and mood. Take part in neurophysiological assessments, including surface EMG, EEG, and reaction time tasks. Have LFP recordings collected using the Medtronic Percept™ device during clinic visits and, where possible, at home using device sensing features. This study will help determine whether LFP analysis can shorten the time to optimal DBS settings and improve outcomes for people with dystonia.
Key facts
- Study ID
- NCT07309133
- Run by
- Newcastle-upon-Tyne Hospitals NHS Trust
- People needed
- 25
- Starts
- 2025-09-04
- Expected to finish
- 2028-12-01
- Last updated by the study team
- 2025-12-30
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 years or older at screening.
- Clear clinical diagnosis of primary dystonia (idiopathic or genetic forms).
- Candidate for GPi DBS surgery for dystonia treatment.
- Able to provide informed consent.
You may not qualify if…
- Significant neurological or psychiatric disorder (including dementia) that would interfere with outcome evaluation.
- Participation in a therapeutic research trial within the last year.
- Diagnosis of functional (psychogenic) dystonia.
Where it is running
- Clinical Ageing Research Unit, — Newcastle upon Tyne, Tyne & Wear, United Kingdom (enrolling)
Full record on ClinicalTrials.gov
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