Limited Versus Extended Lymph Node Dissection During Radical Prostatectomy in Patients With Localized or Locally Advanced Prostate Cancer

Recruiting now · Not applicable

Conditions studied: Prostate Cancer Patients Undergoing Radical Prostatectomy

In brief

This is a randomized controlled study assessing outcome of low (no or limited) versus high (limited or extended) extent of lymph node dissection in addition to radical prostatectomy in patients with operable localized or locally advanced prostate cancer.

Key facts

Study ID

NCT07308990

Run by

N.N. Alexandrov National Cancer Centre

People needed

800

Starts

2025-10-29

Expected to finish

2032-05-30

Last updated by the study team

2025-12-30

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Age over 18 years.
• Histologically confirmed localized or locally advanced prostate cancer (adenocarcinoma without a neuroendocrine component).
• No evidence of metastatic spread of the tumor
• Local resectability of the tumor according to digital rectal examination and/or CT and/or MRI of the pelvis
• Patients are suitable for radical prostatectomy based on their comorbidities and life expectancy.
• Signed informed consent to participate in the study.

You may not qualify if…

• Presence of another active malignant invasive neoplasm.
• Contraindication to pelvic lymph node dissection (e.g., history of radiation therapy to the pelvis).
• The evidence of metastases in regional lymph nodes according to preoperative examination data (including PET/CT with PSMA).
• Severe concomitant disease limiting participation in the study.

Where it is running

• N.N. Alexandrov National Cancer Centre — Lyasny, Minsk Oblast, Belarus (enrolling)

Full record on ClinicalTrials.gov

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