Early Statin-Ezetimibe Combination vs. Statin Monotherapy in Stroke With Atherosclerosis

Recruiting now · Phase 2

Conditions studied: Ischemic Stroke, Hypercholesteremia

In brief

This study will be conducted at six medical institutions in Taiwan, recruiting patients who visit neurology outpatient clinics or are hospitalized within 30 days after an ischemic stroke. Participants will be randomly assigned to either the experimental group (moderate-intensity statin plus ezetimibe) or the control group (moderate- or high-intensity statin). Research assistants will screen patients aged 40 or older who have had an ischemic stroke or transient ischemic attack within 30 days, have atherosclerosis, and have LDL-C levels ≥100 mg/dL. Eligible cases will be reviewed by the attending physician. With physician approval, patients will be invited to join the study, and those who agree and sign informed consent will be enrolled.

Key facts

Study ID: NCT07307989
Run by: Chang Gung Memorial Hospital
People needed: 300
Starts: 2025-08-01
Expected to finish: 2029-07-31
Last updated by the study team: 2025-12-30

Who can join

Age: 20 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

(1) clinical diagnosis of ischemic stroke or TIA; (2) Stroke or TIA symptoms and randomized within 30 days, then taking assigned medication within 2 days of randomization; (3) aged 20 years or older; (4) LDL-C ≥ 100 mg/dL after index ischemic stroke or TIA; (5) having evidence of atherosclerosis.

You may not qualify if…

(1) end stage renal disease because there is no clear benefit of LDL-C lowering therapy in these patients; (2) history of statin intolerance; (3) history of ezetimibe intolerance; or (4) ALT > 100 U/L.(5) Statins were regularly used before stroke. (6) Ezetimibe was used before stroke.

Where it is running

Chang Gung Memorial Hospital, Chiayi Branch — Pozi, Taiwan (enrolling)

Full record on ClinicalTrials.gov

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