Investigation of the Effects of Interlaminar Epidural Steroid Injection on Upper Extremity Proprioception in Patients With Chronic Cervical Radiculopathy

Recruiting now · Not applicable

Conditions studied: Cervical Radiculopathy, Cervical Radicular Pain, Proprioception

In brief

Cervical radiculopathy is a common condition caused by irritation or compression of cervical nerve roots, often leading to unilateral neuropathic pain and functional impairment. Proprioceptive deficits in the upper extremity have been demonstrated in various cervical spine disorders; however, the effect of interlaminar epidural steroid injection (ILESI) on upper extremity proprioception in patients with chronic cervical radiculopathy has not been previously examined. This prospective interventional study aims to evaluate changes in upper extremity proprioception following unilateral ILESI in patients with cervical disc herniation-related chronic radiculopathy. A secondary aim is to investigate the relationship between proprioceptive changes and clinical outcomes such as pain, neuropathic pain, disability, grip strength, and quality of life.

Key facts

Study ID

NCT07307846

Run by

Marmara University

People needed

46

Starts

2026-01-05

Expected to finish

2026-05-01

Last updated by the study team

2026-01-02

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants must meet all of the following:
• Female or male, 18-65 years of age
• Presence of unilateral cervical radicular pain lasting at least 3 months
• MRI of the cervical spine within the last 12 months demonstrating at least one cervical disc herniation consistent with the patient's symptoms
• Diagnosed with chronic cervical radiculopathy based on history, physical examination, and clinical evaluation
• Ability to read and write (literacy)
• Willingness to participate and ability to provide written informed consent

You may not qualify if…

• Participants will be excluded for any of the following:
• Cervical physical therapy or cervical spinal injection performed within the past 6 months
• Symptoms or diagnosis of upper extremity entrapment neuropathy
• Documented vitamin B12 deficiency or vitamin D deficiency on laboratory results within the past year
• History of cervical spine surgery or significant cervical trauma
• Bilateral cervical radicular pain
• Cervical spinal stenosis
• History of upper extremity surgery or significant upper extremity trauma
• Cognitive impairment, major psychiatric disorder, intellectual disability, or history of significant neurological disease
• Diagnosis of polyneuropathy
• Diagnosis of Diabetes Mellitus
• Diagnosis of fibromyalgia
• Current use of medications that may impair proprioception or have sedative effects (e.g., gabapentinoids, antidepressants, muscle relaxants)
• Active local or systemic infection
• Coagulopathy or bleeding diathesis
• Known allergy to any components of the planned injection (triamcinolone, lidocaine, saline, contrast medium)
• Pregnancy
• Inability or unwillingness to provide informed consent
• Illiteracy (unable to read or write)
• Withdrawal Criteria
• Voluntary withdrawal of consent at any time
• Inability or unwillingness to continue study participation for any reason
• New medical condition or event after enrollment that renders continuation unsafe according to the investigator's judgment

Where it is running

• Marmara University Pendik Training and Research Hospital — Pendik, Istanbul, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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