Increasing Germline Genetic Testing for Patients With Cancer

Recruiting now · Not applicable

Conditions studied: Hereditary Pancreatic Cancer, Conditions or Focus of Study, Hereditary Breast Cancer, Hereditary Colorectal Cancer

In brief

Germline testing for hereditary cancer syndromes is underutilized across most health care settings. Using a learning health care approach, the Genomics-enabled Learning Health Systems (gLHS) network aims to evaluate the impact of a suite of implementation strategies to increase germline test ordering by oncology care teams (i.e., mainstreaming) for eligible patients with breast, pancreatic or colorectal cancer. Secondarily, the study will investigate completion of testing by eligible patients, as well as impact on overall rates of germline test ordering in patients with cancer. The network will bundle and deploy different implementation strategies across the clinical sites in three 6-month phases. A maintenance phase after the implementation periods will measure genetic testing rates without any additional implementation strategies to determine persistence of effects. The implementation strategies address clinician-level factors, and thus oncologists and their team members (e.g. advanced practice providers, nurse navigators, case managers) will be the focus of evaluating the impact of implementation strategies. Strategies that will be considered include provider education, audit and feedback reports, facilitation, peer support, and electronic health record (EHR) system optimization to support germline testing. Using the RE-AIM QuEST framework, outcomes will be assessed using mixed methods separately for each eligible cancer type. Data collection from the EHR, other relevant data sources, and qualitative provider feedback will be used to assess ordering and completion of tests and the effect of the implementation strategies on germline testing rates in oncology clinics.

Key facts

Study ID

NCT07307664

Run by

Josh Peterson

People needed

1000

Starts

2026-01-30

Expected to finish

2030-01-01

Last updated by the study team

2026-06-09

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Oncology care team members (including, but not limited to, oncologists, advanced practice providers, nurse navigators, caring for patients with adult patients with breast cancer, pancreatic cancer or colorectal cancer.

You may not qualify if…

• Providers not on the oncology care team

Where it is running

• VA Greater Los Angeles Healthcare System — Los Angeles, California, United States (enrolling)
• Orlando VA Medical Center — Orlando, Florida, United States (enrolling)
• Atlanta VA Medical Center — Decatur, Georgia, United States (enrolling)
• Northwestern Medicine — Chicago, Illinois, United States (enrolling)
• Indiana University School of Medicine — Indianapolis, Indiana, United States (enrolling)
• Durham VA Medical Center — Durham, North Carolina, United States (enrolling)
• Salisbury VA Health Care System — Salisbury, North Carolina, United States (enrolling)
• Geisinger — Danville, Pennsylvania, United States (enrolling)
• Vanderbilt University Medical Center — Nashville, Tennessee, United States (enrolling)
• University of Utah Health — Salt Lake City, Utah, United States (enrolling)

Full record on ClinicalTrials.gov

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