To Evaluate Early (2-Week) vs. Standard (4-Week) Metal Stent Removal Following Endoscopic Ultrasound Guided WON Drainage

Recruiting now · Not applicable

Conditions studied: Walled Off Necrosis

In brief

In adults with walled-off pancreatic necrosis (WON) undergoing endoscopic ultrasound (EUS)-guided transluminal necrosectomy, does early removal of the lumen-apposing metal stent (LAMS) (at 2 weeks or immediately after the last necrosectomy) with placement of a double-pigtail plastic stent (DPT), compared to delayed LAMS removal at 4 weeks without a DPT, result in a lower rate of pancreatic fluid collection (PFC) recurrence or need for reintervention over 12 months.

Key facts

Study ID: NCT07307248
Run by: Asian Institute of Gastroenterology, India
People needed: 408
Starts: 2025-12-25
Expected to finish: 2028-12-31
Last updated by the study team: 2026-01-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Age ≥18 years
Patients with walled-off pancreatic necrosis (WON) undergoing endoscopic ultrasound-guided drainage with lumen-apposing metal stent (LAMS)
Radiological resolution of the pancreatic fluid collection ≥70% at 2 weeks after index endoscopic drainage, assessed on cross-sectional imaging (CT or MRI)

You may not qualify if…

Presence of chronic pancreatitis
Pancreatic malignancy (suspected or confirmed)
Incomplete endoscopic necrosectomy or persistent large necrotic debris on imaging at 2 weeks after drainage
Occurrence of major procedure-related adverse events within the first 2 weeks, including:
Clinically significant bleeding
Infection requiring additional intervention
Stent migration
Inability or unwillingness to provide written informed consent

Where it is running

Asian Institute of Gastroenterology — Hyderabad, Telangana, India (enrolling)

Full record on ClinicalTrials.gov

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