Pilot Study for the Evaluation of a New Psychotherapeutic Treatment for Borderline Personality Disorder Patients With Post-traumatic Stress Symptoms
Starting soon · Not applicable
Conditions studied: Borderline Personality Disorder (BPD), PTSD - Post Traumatic Stress Disorder
In brief
Borderline Personality Disorder (BPD) is a serious mental health condition that often co-occurs with Complex PTSD (CPTSD), making treatment more challenging. Trauma-Focused Mentalization-Based Treatment (MBT-TF) is a new adaptation of standard MBT designed for individuals with high trauma exposure. Early findings are promising, but further research is needed. This study at Geneva University Hospitals (HUG) will test the feasibility and acceptability of MBT-TF compared with standard MBT, gathering feedback from patients and clinicians and laying the groundwork for a larger clinical trial.
Key facts
- Study ID
- NCT07305155
- Run by
- Eva Rüfenacht
- People needed
- 40
- Starts
- 2026-06-01
- Expected to finish
- 2030-12-01
- Last updated by the study team
- 2026-02-06
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age between 18 and 65 years.
- Meeting ≥4 of 9 SCID-5 PD criteria associated with functional impairment (either subthreshold or full BPD diagnosis), and an LPFS-BF 2.0 score ≥31 (≥1.5 standard deviations above the latent mean, T-score ≥65), indicating moderate to severe personality disorder features.
- Diagnosis of CPTSD according to ICD-11 criteria, confirmed via ITQ with clinical checks.
You may not qualify if…
- Mental disability.
- Severe psychiatric psychopathology requiring immediate treatment (e.g., BMI <16.5, acute bipolar episode, current psychosis).
- Severe active substance dependence.
- Severe physical health problems (e.g., severe cardiovascular conditions). Severe neurological disorder.
Where it is running
- University Hospitals of Geneva — Geneva, Canton of Geneva, Switzerland
Full record on ClinicalTrials.gov
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