Preventing Muscle Loss After Bariatric Surgery: Protein-Collagen Supplementation and Resistance Exercise

Recruiting now · Not applicable

Conditions studied: Bariatric Surgery, Muscle Loss

In brief

The aim of this clinical trial is to investigate the effectiveness of collagen, considered a new approach to prevent muscle mass loss after bariatric surgery, and to demonstrate the relationship between this effect and exercise. The key questions it aims to answer are: Does whey protein supplementation with collagen combined with resistance exercise prevent muscle mass loss after bariatric surgery? Do whey protein supplementation with collagen combined with resistance exercise affect fat mass after bariatric surgery? Researchers will compare collagen with whey protein. The study groups and interventions to be implemented are summarized below: Group 1: Control Group (CG; n: 10) Whey protein supplementation will be administered Vitamin and mineral supplementation will be administered No resistance exercise will be performed The participants will eat according to bariatric surgery nutrition guidelines and perform physical activities. Group 2: Whey Protein + Collagen + Exercise Group (WPCEG; n: 10) Whey protein supplements with collagen will be given. Vitamin and mineral supplements will be given. Resistance exercise will be performed. They will eat according to bariatric surgery nutrition guidelines and perform physical activities. They will begin a resistance exercise program 4 weeks after surgery. Group 3: Whey Protein + Collagen + No Exercise Group (WPCG; n: 10) Whey protein supplements with collagen will be given. Vitamin and mineral supplements will be given. No resistance exercise will be performed. They will eat according to bariatric surgery nutrition guidelines and perform physical activities. Group 4: Whey Protein + Exercise Group (WPEG; n: 10) Whey protein supplements will be given. Vitamin and mineral supplements will be given. Resistance exercise will be performed. They will eat according to bariatric surgery nutrition guidelines and perform physical activities. A resistance exercise program will begin at 4 weeks post-operatively.

Key facts

Study ID

NCT07303543

Run by

Medipol University

People needed

35

Starts

2022-08-02

Expected to finish

2026-01-30

Last updated by the study team

2025-12-26

Who can join

Age: 20 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Being between 20-50 years old
• Body mass index; 35 ≤ BMI< 60 kg/m2
• Not being pregnant
• Not being addicted to alcohol and drugs
• Not having entered menopause
• No exercise restrictions

You may not qualify if…

• Having at least one of the following inflammatory bowel diseases, upper gastrointestinal bleeding, advanced psychiatric diseases, cancer, and kidney failure.
• using statins
• be pregnant
• Being addicted to alcohol and drugs
• to have entered menopause
• Having exercise restrictions
• Becoming a professional athlete
• Having done more than 60 minutes of regular and structured exercise per week in the last year

Where it is running

• Istanbul Medipol University — Istanbul, Fatih, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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