One-stage Exchange in Candida Periprosthetic Infection a Suitable Way to go

Recruiting now

Conditions studied: Candida Infection

In brief

Accounting for only 0.7% to 3% of joint prosthesis infections, yeast infections are considered particularly difficult to treat. They are primarily caused by Candida yeasts, representing over 90% of cases. Surgical treatment is the cornerstone of managing periprosthetic infections. In cases of chronic bacterial infections, complete implant replacement is necessary and can be performed either in one or two stages. However, for chronic Candida spp. infections, two-stage prosthesis replacement remains the preferred option. Only three retrospective, single-center studies have evaluated the success rate of one-stage prosthesis replacement in periprosthetic Candida spp. infections in selected patients. Although the sample sizes of these studies are small, the 2-year success rate of 63% to 81% differs little from that of two-stage implant replacement (47% to 100%). Furthermore, systemic antifungal treatment is poorly defined. Recommendations are based on studies with a low level of evidence. The hypothesis is that a single-stage prosthesis replacement combined with appropriate antifungal treatment for chronic periprosthetic Candida spp. infection has the same outcome as a two-stage prosthesis replacement.

Key facts

Study ID

NCT07303101

Run by

University Hospital, Strasbourg, France

People needed

16

Starts

2025-05-28

Expected to finish

2026-02-01

Last updated by the study team

2025-12-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient aged over 18 years at the time of prosthesis revision
• Operated on at the Strasbourg University Hospitals (HUS) between January 1, 2013, and December 31, 2021
• Hip or knee prosthesis revision
• Possible or proven periprosthetic Candida spp. infection according to the EBJIS diagnostic criteria
• Minimum of 3 deep samples (joint fluid, preoperative sample, and/or prosthesis sonication)

You may not qualify if…

• Patient undergoing lavage, synovectomy, and implant preservation
• Patient not receiving systemic antifungal treatment after prosthesis replacement
• Patient with another proven Candida spp. infection or infective endocarditis
• Patient for whom suppressive therapy was prescribed prior to surgery.

Where it is running

• Service de Chirurgie Orthopédique Septique - CHU de Strasbourg - France — Strasbourg, France (enrolling)

Full record on ClinicalTrials.gov

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