Platelet Serotonin Deficiencies: the Strasbourg Experience

Recruiting now

Conditions studied: Hemorrhagic Syndrome

In brief

Hemorrhagic syndromes are investigated using algorithms established by reference centers and hemostasis societies. The investigation of platelet dense granules (nucleotide and serotonin testing) is part of the second-line tests. It can be performed in cases of platelet aggregation abnormalities in platelet-rich plasma (PRP) suggesting a secretion abnormality, or in cases where the latter is normal, it can be performed if the patient's clinical presentation points to a primary hemostasis abnormality and the clinician wishes to pursue further investigations Intraplatelet serotonin deficiencies are often iatrogenic and may be accompanied by bleeding. Their impact on platelet function is poorly documented.

Key facts

Study ID

NCT07302087

Run by

University Hospital, Strasbourg, France

People needed

50

Starts

2024-11-25

Expected to finish

2026-02-01

Last updated by the study team

2025-12-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patient (≥ 18 years old)
• Treated at Strasbourg University Hospital for a hemorrhagic syndrome, suggesting a primary hemostasis abnormality and normal von Willebrand factor, during the period from January 1, 2023, to April 1, 2024.

You may not qualify if…

• Refusal to participate in the study

Where it is running

• Centre de Ressources et de Compétences des Maladies Hémorragiques Constitutionnelles - CHU de Strasbourg - France — Strasbourg, France (enrolling)

Full record on ClinicalTrials.gov

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