Low-Tech Treatments for Obstructive Sleep Apnea

Recruiting now · Phase 1/Phase 2 · Has a placebo group

Conditions studied: Obstructive Sleep Apnea (OSA), Traumatic Brain Injury (TBI)

In brief

The overall purpose of this study is to compare changes in sleep outcomes in people with obstructive sleep apnea (OSA) depending on their participation in one of two behavioral interventions; both involve drinking water and breathing. A second purpose is to compare outcomes between people who have sustained a traumatic brain injury (TBI) and those with no history of TBI. The main questions it aims to answer are whether sleep quality improves after 3-months of high-resistance versus low-resistance exercises, and whether people have different outcomes depending on their history of TBI.

Key facts

Study ID: NCT07301710
Run by: Uniformed Services University of the Health Sciences
People needed: 60
Starts: 2026-01-29
Expected to finish: 2027-12-01
Last updated by the study team: 2026-02-17

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

New diagnosis of OSA (AHI, ≥ 5) or failure of first-line OSA treatment;
Willingness to forego first-line OSA treatment or stop current OSA treatment for 3 months;
Ability to follow directions and perform the required exercises;
Age between 18-65 yr.

You may not qualify if…

Current use of OSA treatment;
Medical comorbidities that require restricting fluid intake (e.g., dysphagia, renal disease, liver disease, hyponatremia);
Severe nasal obstruction; 4) severe ankyloglossia; 4) craniofacial abnormality; 5) severe pulmonary disease; 6) severe post-traumatic stress disorder; 7) very severe insomnia; 8) body mass index (BMI) ≥30 kg/m2

Where it is running

Walter Reed National Military Medical Center — Bethesda, Maryland, United States (enrolling)

Full record on ClinicalTrials.gov

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