Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) for Perioperative Hemodynamic Optimization in Patients Under General Anesthesia

Recruiting now · Not applicable

Conditions studied: Intraoperative Hypotension

In brief

This study investigates if the Hypotension Prediction Index (HPI) combined with the Assisted Fluid Management (AFM) software can improve perioperative hemodynamic management in adult patients undergoing general anesthesia. The main question is : Does the HPI and AFM software reduce the incidence and duration of intraoperative hypotension? Does the HPI and AFM software optimize fluid and vasopressor administration? Does the HPI and AFM software improve perioperative outcomes? Participants will be randomly allocated to either an experimental group receiving goal directed hemodynamic therapy guided by HPI and AFM or a control group receiving conventional hemodynamic management.

Key facts

Study ID

NCT07301307

Run by

National and Kapodistrian University of Athens

People needed

100

Starts

2026-03-15

Expected to finish

2027-03-01

Last updated by the study team

2026-04-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age > 18 years
• Intraoperative monitoring > 2 hours or general anesthesia > 2 hours
• Invasive arterial pressure monitoring
• Target MAP ≥ 65 mm Hg intraoperatively
• Written informed consent preoperatively
• ASA Physical Status ≤ 4

You may not qualify if…

• Target MAP other than 65 mm Hg
• Severe preoperative hypotension (MAP < 65 mm Hg)
• Severe heart failure (e.g. LVEF < 20%)
• Emergency surgery

Where it is running

• 2nd University Department of Anesthesiology, Attikon University Hospital — Athens, Attica, Greece (enrolling)

Full record on ClinicalTrials.gov

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