Velopharyngeal Insufficiency After Maxillomandibular Advancement Osteotomy in Obstructive Sleep Apnea Patients

Starting soon

Conditions studied: Velopharyngeal Insufficiency, Swallowing, Nasality, Speech

In brief

The aim of this study is to gain insight into the development of velopharyngeal insufficiency (VPI) in patients who have undergone maxillomandibular advancement osteotomy (MMA) as a treatment for obstructive sleep apnea syndrome (OSAS). A speech therapist evaluates nasality, speech, and swallowing before and after the surgery.

Key facts

Study ID

NCT07301021

Run by

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

People needed

28

Starts

2026-05-01

Expected to finish

2027-12-01

Last updated by the study team

2026-03-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age > 18 years
• Mild to severe OSA
• Indication for MMA for OSA treatment

You may not qualify if…

• patients who underwent other adjunctive procedures at the time of MMA (e.g., multipiece le Fort osteotomy, TMJ reconstruction
• Previous history of orthognathic surgery
• Previous history of orthognathic surgery
• Previous history of oropharyngeal surgery (UPPP or multi-level surgery)
• Cleft palate and syndromic patients
• Neuromusculair diseases which causes VPI, dysphagia or dysarthria
• Incapacity

Where it is running

• Amsterdam UMC — Amsterdam, North Holland, Netherlands

Full record on ClinicalTrials.gov

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