Functional MRI for Monitoring Progression and Assessing Trends in ILD

Recruiting now · Not applicable

Conditions studied: Interstitial Lung Diseases (ILD)

In brief

The main objective of this study is to investigate the utility of functional MRI to differentiate, characterize, and monitor subgroups of ILD. This can be broken down into three specific objectives: Determine if ILD features observed on high-resolution computed tomography (HRCT), such as ground glass opacities (GGO), are functionally different. Analyse MRI metrics within each subgroup to determine whether these metrics distinguish different ILDs. Assess MRI metrics longitudinally to see if these parameters change with disease progression, stability, or reversibility.

Key facts

Study ID

NCT07300696

Run by

University Hospital Heidelberg

People needed

200

Starts

2025-11-20

Expected to finish

2027-07-01

Last updated by the study team

2025-12-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical indication for a routine HRCT because of either newly diagnosed idiopathic pulmonary fibrosis (IPF) or hypersensitivity pneumonitis (HP) or idiopathic non-specific interstitial pneumonia (iNSIP), suspected diagnosis, or follow-up
• Capacity to consent
• Ability to participate fully in the study (defined by the ability to lie still for the duration of imaging)

You may not qualify if…

• Pregnancy and breast feeding
• Persons under the age of 18 and persons not able to give informed consent
• Any medical conditions that could hinder the ability to adhere to the protocol
• Any MRI contraindication, including previous allergic reactions to Gd-based MRI contrast material and renal dysfunction (eGFR < 30 ml min/1,73 m2)

Where it is running

• Thoraxklink Heidelberg - Universitätsklinikum Heidelberg — Heidelberg, Germany (enrolling)
• Universitätsklinikum Schleswig-Holstein, Campus Kiel — Kiel, Germany

Full record on ClinicalTrials.gov

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