Vascular Events in Noncardiac Surgery Patients Cohort Evaluation Study 2

Starting soon

Conditions studied: Myocardial Injury After Noncardiac Surgery (MINS), Bleeding Independently Associated With Mortality After Noncardiac Surgery (BIMS), Sepsis, Infection Without Sepsis, Post-operative Complications

In brief

VISION-2 is an international, multi-site, prospective observational cohort study of 20,000 patients undergoing noncardiac surgery. Continuous biometric data will be blindly collected for the first 30 postoperative days, in hospital and at home, using Vitaliti™. Following study enrollment and baseline data collection, follow up visits will occur in-hospital, at 30-days, and 1-year post-operatively. VISION-2 has 3 primary objectives, among participants who underwent noncardiac surgery, the investigators will: 1) determine the pattern and frequency of physiological precursors (i.e., biophysical signals) to MINS, BIMS, sepsis, and infection without sepsis; 2) build prediction models from these biophysical signals and their extracted features through supervised machine learning, for the prediction and early detection of those complications; and 3) build a biobank for evaluation of novel biomarkers.

Key facts

Study ID

NCT07300579

Run by

Hamilton Health Sciences Corporation

People needed

20000

Starts

2026-06-01

Expected to finish

2032-06-01

Last updated by the study team

2026-04-14

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age ≥65 years;
• underwent non-cardiac surgery with general, neuraxial, local, or regional anesthesia; and
• expected length of hospital stay of 3 or more days

You may not qualify if…

• hearing aid(s) or cochlear implant(s) in left ear;
• pacemaker/implantable cardioverter-defibrillator (ICD);
• externally programmable cerebrospinal fluid shunt;
• deep brain stimulator;
• intolerance/allergy to adhesive;
• history of dementia, or;
• previous enrollment in the VISION-2 Study

Where it is running

• Hamilton General Hospital — Hamilton, Ontario, Canada
• St. Joseph's Healthcare Hamilton — Hamilton, Ontario, Canada
• Juravinski Hospital & Cancer Centre — Hamilton, Ontario, Canada

Full record on ClinicalTrials.gov

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