A Clinical Study of Novel Pneumococcal Vaccine V118C in Children (V118C-002)
Recruiting now · Phase 1
Conditions studied: Pneumococcal Infection
In brief
Researchers are looking for new vaccines to prevent pneumococcal disease, which is any infection in the lungs or other parts of the body that is caused by a type of bacteria called Streptococcus pneumoniae. V118C is a new vaccine designed to help prevent disease from Streptococcus pneumoniae bacteria. This study will look at V118C in toddlers and infants. The goal of the study is to learn how safe V118C is for children and how well they tolerate it.
Key facts
- Study ID
- NCT07300267
- Run by
- Merck Sharp & Dohme LLC
- People needed
- 210
- Starts
- 2026-01-13
- Expected to finish
- 2029-05-25
- Last updated by the study team
- 2026-04-17
Who can join
Age: 0 and older, up to 1. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- The main inclusion criteria include but are not limited to the following:
- Stage 1:
- Is previously vaccinated with 3 routine infant doses of Pneumococcal 20-valent conjugate vaccine (PCV20)
- Is 12 through 15 months of age
- Stage 2:
- Is approximately 2 months of age
- Both Stages:
- Was born at full term (gestational age greater than or equal to 37 weeks)
You may not qualify if…
- The main exclusion criteria include but are not limited to the following:
- Stage 1:
- Has received a PCV dose at 10 months of age and older
- Stage 2:
- Has received prior administration of any pneumococcal vaccine
- Both stages:
- Has a history of invasive pneumococcal disease (IPD)
- Has a known hypersensitivity to any component of V118C or PCV20 including diphtheria toxoid
Where it is running
- Madera Family Medical Group ( Site 1004) — Madera, California, United States (enrolling)
- Acevedo Clinical Research Associates ( Site 1029) — Miami, Florida, United States (enrolling)
- University of South Florida-Department of Pediatrics ( Site 1002) — Tampa, Florida, United States (enrolling)
- Cotton O'Neil Research Center ( Site 1039) — Topeka, Kansas, United States (enrolling)
- University of Louisville, Norton Children's Research Institute ( Site 1005) — Louisville, Kentucky, United States (enrolling)
- The Pediatric Center ( Site 1025) — Columbia, Maryland, United States (enrolling)
- Saint Louis University Center for Vaccine Development ( Site 1031) — St Louis, Missouri, United States (enrolling)
- Child Health Care Associates ( Site 1035) — East Syracuse, New York, United States (enrolling)
- Tribe Clinical Research, LLC-Pediatrics ( Site 1008) — Greenville, South Carolina, United States (enrolling)
- Tribe Clinical Research - Spartanburg ( Site 1001) — Spartanburg, South Carolina, United States (enrolling)
- Epic Medical Research - Carrollton ( Site 1038) — Carrollton, Texas, United States (enrolling)
- Epic Medical Research- Garland ( Site 1017) — Garland, Texas, United States (enrolling)
- University of Texas Medical Branch ( Site 1020) — League City, Texas, United States (enrolling)
- Pediatric Research of Charlottesville, LLC ( Site 1012) — Charlottesville, Virginia, United States (enrolling)
Full record on ClinicalTrials.gov
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