Perineural Dexamethasone, Dexmedetomidine, or Their Combination to Reduces Rebound Pain After Supraclavicular Brachial Plexus Block

Starting soon · Phase 4

Conditions studied: Brachial Plexus Blocks

In brief

Dexmedetomidine, an α2 adrenoceptor agonist, and dexamethasone, a potent anti-inflammatory steroid, are commonly used, effective, and safe adjuvants to peripheral nerve block (PNB). Both have been found to delay and reduce the incidence of rebound pain (RP), prolong the duration of sensory and motor block, and enhance analgesia without causing significant respiratory depression. Few studies have explored the effectiveness of dexmedetomidine or dexamethasone as sole adjuvants to PNB for preventing or reducing RP. However, no study has directly compared the effectiveness of these two drugs in reducing RP when used as adjuvants to local anesthetic (LA) in PNB. Due to differences in their mechanism of action, their effects on RP may differ significantly. The investigators hypothesized that the combination of dexamethasone and dexmedetomidine reduces the incidence of RP when used as adjuvants to LA in PNB.

Key facts

Study ID

NCT07299877

Run by

Al-Azhar University

People needed

75

Starts

2025-12-28

Expected to finish

2026-10-15

Last updated by the study team

2026-01-09

Who can join

Age: 20 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• from 20-65 years old
• and ASA physical status I or II and III,
• and of either gender,
• who provided informed, written, and valid consent,
• were scheduled for elective orthopedic upper limb surgeries for traumatic fractures under Supraclavicular Brachial Plexus Block.

You may not qualify if…

• Patients with coagulopathies,
• neurological disorders,
• hypersensitivity to any of the study drugs, or
• a history of previous surgeries on the affected limb
• and those who refused to sign informed consent

Where it is running

• Benha University, Faculty of Medicine — Banhā, Qalyubiyya, Egypt

Full record on ClinicalTrials.gov

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