Analysis of Pharmacological Aspects Regarding Infection Free Survival After Surgical Treatment of a Periprosthetic Knee Infection: a Microdialysis Study

Recruiting now

Conditions studied: Periprosthetic Knee Infection

In brief

This study aims to use the technique of microdialysis to analyse the intraarticular space of the knee joint after removal of a periprosthetic joint infection affected endoprosthesis and implantation of an antibiotic-containing cement spacer over the entire period of the first hospitalization (usually 14 days) to closely monitor pharmacological and immunological aspects. In detail, antibiotic concentrations in the joint cavity and systemic circulation will be assessed according to reinfection rates, infection-free survival and fucntional outcome over a 12-month folluw-up period.

Key facts

Study ID

NCT07299565

Run by

University Hospital, Bonn

People needed

30

Starts

2025-11-15

Expected to finish

2027-11-01

Last updated by the study team

2025-12-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• clinical indication for two-stage revision of knee PJI
• approval for surgery by the orthopedic and anesthesiologic department
• being over 18 years of age
• written, informed consent after detailed patient information about the study protocol and possible study dependent risks

You may not qualify if…

• known allergies to antibiotics gentamicin and vancomycin used within the spacer

Where it is running

• University Hospital Bonn — Bonn, North Rhine-Westphalia, Germany (enrolling)

Full record on ClinicalTrials.gov

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