Assessing Fluid-responsiveness Using Non-invasive Hybrid Diffuse Optics on Peripheral Muscle

Recruiting now

Conditions studied: Critical Illness

In brief

Proof-of-concept observational study including ICU patients undergoing a PLR maneuver. Local microvasculature will be assessed with the hDOS platform on the brachioradialis muscle, deriving the microvascular blood flow index (BFI) and tissue oxygen saturation (StO2). CO will be assessed via an invasive hemodynamic monitor based on pulse waveform analysis through the patient's arterial line. The correlation over time between CO and microvascular parameters, and the ability of microvascular variables for predicting a positive CO response (increase \> 10%) will be assessed.

Key facts

Study ID

NCT07298720

Run by

Corporacion Parc Tauli

People needed

200

Starts

2025-01-07

Expected to finish

2027-01-01

Last updated by the study team

2026-03-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Invasive blood pressure monitoring through an arterial line

You may not qualify if…

• Patients with suspected pregnancy
• Intra-abdominal hypertension
• Elevated intracranial pressure

Where it is running

• Parc Taulí Hospital Universitari — Sabadell, Spain/ Barcelona, Spain (enrolling)

Full record on ClinicalTrials.gov

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