Mechanisms of Maternal Immune Tolerance in Early Pregnancy

Recruiting now

Conditions studied: Pregnancy, Immune Tolerance, In Vitro Fertilization

In brief

This study explores the mechanisms of maternal immune tolerance in early pregnancy by characterizing immune cell profiles and functional pathways during the first trimester. The goal is to identify immunological factors that support healthy gestation and prevent complications such as miscarriages.

Key facts

Study ID

NCT07297394

Run by

University Hospital, Basel, Switzerland

People needed

100

Starts

2026-03-02

Expected to finish

2030-12-01

Last updated by the study team

2026-03-04

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Blood from patients will be included before and during pregnancies (or failed implantation) conceived through IVF/ICSI (Intracytoplasmic Sperm Injection) treatment and in case of miscarriage.
• where the patient (pregnant person) was ≥ 18 years of age.
• where the patient (pregnant person) signed a written informed consent.

You may not qualify if…

• Certain maternal infections (HIV, Hepatitis B, Hepatitis C, Syphilis)
• Patients under immunosuppressive medications (at time of blood sample collection)

Where it is running

• University Hospital Basel — Basel, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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