International Genetic Obesity Registry

Recruiting now

Conditions studied: Genetic Obesity

In brief

Genetic obesity results from changes in specific genes that affect appetite regulation, metabolism, and fat storage. Its severity and associated health issues vary depending on the genetic cause. In some cases, hormonal imbalances, developmental delays, or other complications may also occur. Identifying the genetic cause is essential for personalized treatment and understanding potential symptoms. As genetic obesity is rare, specialists often encounter few patients with diverse genetic backgrounds and clinical features. Therefore, collecting global data is crucial to improve our understanding of the condition's progression, complications, and treatment responses for each genetic subtype. To support this, the International Genetic Obesity Registry (iGO Registry) has been established to gather detailed patient information on genetic obesity. This registry will help advance research and improve clinical care for affected individuals. It will collect data from routine outpatient visits, focusing on relevant diagnostic and treatment information on an international level.

Key facts

Study ID

NCT07296900

Run by

University of Ulm

People needed

5000

Starts

2025-11-17

Expected to finish

2075-11-01

Last updated by the study team

2025-12-22

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with
• genetically confirmed genetic obesity (ACMG classification 3-5, associated with obesity) and/or
• early onset severe obesity (BMI ≥ 120% 95th percentile or ≥ 35 kg/m2 before 5 years of age) if genetic testing was performed
• Capable of understanding the aims of the protocol and to provide informed consent (for children and chronically incapacitated individuals, consent is given by their legal guardians)

You may not qualify if…

• Not capable of understanding the aims of the protocol and to provide informed consent

Where it is running

• Ulm University Clinic — Ulm, Germany (enrolling)

Full record on ClinicalTrials.gov

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