Effect of Sevoflurane vs Desflurane on Mechanical Power in Laparoscopic Cholecystectomy

Recruiting now · Not applicable

Conditions studied: Perioperative Respiratory Mechanics

In brief

This single-center, prospective, randomized, assessor-blinded clinical trial aims to compare the effects of sevoflurane and desflurane anesthesia on intraoperative mechanical power in adult patients undergoing elective laparoscopic cholecystectomy. Mechanical power will be measured at three standardized time points using a validated formula, and secondary outcomes include driving pressure values and early postoperative respiratory complications (desaturation, laryngospasm, bronchospasm, cough).

Key facts

Study ID

NCT07295158

Run by

Konya City Hospital

People needed

138

Starts

2026-03-09

Expected to finish

2026-08-30

Last updated by the study team

2026-07-20

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18-65 years
• ASA Physical Status I-II
• Scheduled for elective laparoscopic cholecystectomy
• Able to provide written informed consent

You may not qualify if…

• Known hypersensitivity or contraindication to study medications (sevoflurane or desflurane)
• Severe chronic obstructive pulmonary disease (COPD)
• Uncontrolled bronchial asthma
• Decompensated heart failure (NYHA Class III-IV)
• History of prior lung surgery
• Morbid obesity (BMI > 35 kg/m²)
• Pregnancy
• Refusal to participate or inability to provide informed consent

Where it is running

• Konya City Hospital — Konya, Konya, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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