Impact of Lifestyle Interventions on Cognitive Decline in Non-alcoholic Fatty Liver Disease

Recruiting now · Not applicable

Conditions studied: Non-Alcoholic Fatty Liver Disease, Neurocognitive Disorders

In brief

This study investigates whether a structured lifestyle program can help improve thinking skills and liver health in adults with Non-Alcoholic Fatty Liver Disease (NAFLD). We are enrolling 45 participants, aged 18-42, who will be randomly assigned to one of three groups for six months: one receiving general health advice, a second following a supervised Mediterranean diet plan, and a third combining the same diet with a regular walking program. The main goal is to see if these diet and exercise interventions can lead to better scores on memory and reasoning tests, reduce liver stiffness measured by a painless scan (FibroScan), and improve related blood markers of inflammation and hormone balance.

Key facts

Study ID

NCT07294963

Run by

Khyber Medical University Peshawar

People needed

45

Starts

2025-10-01

Expected to finish

2026-06-15

Last updated by the study team

2025-12-19

Who can join

Age: 18 and older, up to 42. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 to 42 years.
• Diagnosed with fatty liver (NAFLD) via imaging (e.g., ultrasound).
• Liver fibrosis assessed and staged via FibroScan and the FIB-4 index.
• Literate (to consent and complete cognitive assessments/questionnaires).

You may not qualify if…

• History of alcohol intake >20g/day.
• Chronic viral hepatitis B or C.
• Major neuropsychiatric illnesses.
• Pregnancy or breastfeeding.
• Chronic illnesses including Diabetes Mellitus and thyroid dysfunction.

Where it is running

• Khyber Teaching Hospital — Peshawar, KPK, Pakistan (enrolling)
• Northwest General Hospital — Peshawar, KPK, Pakistan (enrolling)

Full record on ClinicalTrials.gov

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